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KMID : 1151820170110070589
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Journal of the Korean Society of Radiology
2017 Volume.11 No. 7 p.589 ~ p.595
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Quantitative Comparison of 1H-MRS Spectra Depending on the Paramagnetic Gadolinium Contrast Agent(GBCA) Injection
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Choi Kwan-Woo
Son Soon-Yong
Yoo Beong-Gyu
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Abstract
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This study evaluated the effect of gadolinium contrast agents on the spectrum of metabolites during 1H-MRS of brain and to investigate whether the contrast agents injected before MR spectroscopy significantly affect the estimated peaks of MRS. From January to May 2017, brain MR spectroscopy was performed on 30 patients to compare the spectrum before and after contrast injection of the brain white matter tissue. As a result, the spectrum of metabolites decreased after the paramagnetic contrast agents injected. However, it was not statistically significant which indicated that the use of contrast agent did not meaningfully affect the spectrum of metabolites. In conclusion, the use of the paramagnetic contrast before the acquisition of the spectroscopy may aid voxel positioning especially when it is difficult to determine the exact location of the lesion or the contrast is low.
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KEYWORD
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Proton Magnetic Resonance Spectroscopy, 1H-MRS, Gadolinium based contrast agent, Point Resolved Spectroscopy, LC model, Brain White matter
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